Genome location: Pf3D7_01_v3:69,304..70,417(-)
Genome classification: SubtelomericHypervariable
Product Description: exported protein family 4
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.00 | 1.00 |
| Trophozoite | no data | nd | 1.00 |
| Schizont | no data | nd | 1.00 |
| Gametocyte | no data | nd | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0101100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.151 | MFS: -2.77 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 76
Non-coding: 15 | Synonymous: 55 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 309 | Molecular Weight (kDa): 35.716
UniProt ID(s): O97308
PDB ID(s): None
Isoelectric Point: 10.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23517413 | Novel Plasmodium falciparum Maurer's clefts protein families implicated in therelease of infectious merozoites. | Mbengue A, Audiger N, ..., Braun-Breton C | 10.1111/mmi.12193 |