Product Description: ring-infected erythrocyte surface antigen
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0044228 | host cell surface |
| Component | GO:0020026 | merozoite dense granule |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
| Process | GO:0050776 | regulation of immune response |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 4.42 | 0.07 |
| Trophozoite | expressed | 2.14 | 0.23 |
| Schizont | expressed | 2.30 | 0.16 |
| Gametocyte | possibly expressed | 1.37 | 0.46 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0102200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.166 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0U6
"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=2.90) with 5AYK (Global RMSD=9.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 19 | 9 | 21 |
| disruptive | 61 | 72 | 34 | 80 |
| missense | 35 | 40 | 28 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 47 | 14 | 47 |
| disruptive | 98 | 183 | 62 | 146 |
| missense | 53 | 135 | 51 | 104 |
PlasmoDB Total SNPs: 370
Non-coding: 109 | Synonymous: 186 | Nonsynonymous: 74 | Stop Codon: 1
Protein Length: 1085 | Molecular Weight (kDa): 126.521
UniProt ID(s): Q7M3R2, Q8I0U6, Q9U413
PDB ID(s): None
Isoelectric Point: 4.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| InterPro | IPR026894 | DNAJ-containing protein, X-domain |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| PFam | PF14308 | DNAJ-containing protein, X-domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF69349 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 1997422 | Plasmodium falciparum ring-infected erythrocyte surface antigen is released frommerozoite dense granules after erythrocyte invasion. | Culvenor JG, Day KP, Anders RF | 10.1128/iai.59.3.1183-1187.1991 |
| 2209790 | Pf155/RESA antigen is localized in dense granules of Plasmodium falciparummerozoites. | Aikawa M, Torii M, ..., Miller LH | 10.1016/0014-4894(90)90037-d |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15853885 | A role for the Plasmodium falciparum RESA protein in resistance against heatshock demonstrated using gene disruption. | Silva MD, Cooke BM, ..., Bonnefoy S | 10.1111/j.1365-2958.2005.04603.x |
| 17468340 | The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparumstabilizes spectrin tetramers and suppresses further invasion. | Pei X, Guo X, ..., An X | 10.1182/blood-2007-02-076919 |
| 17517609 | Effect of plasmodial RESA protein on deformability of human red blood cellsharboring Plasmodium falciparum. | Mills JP, Diez-Silva M, ..., Suresh S | 10.1073/pnas.0703433104 |
| 19816792 | Molecular cloning and characterisation of the RESA gene, a marker of geneticdiversity of Plasmodium falciparum. | Moyano EM, Gonzalez LM, ..., Benito A | 10.1007/s11033-009-9849-z |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22533816 | Possible association of the Plasmodium falciparum T1526C resa2 gene mutation withsevere malaria. | Durand R, Migot-Nabias F, ..., Bonnefoy S | 10.1186/1475-2875-11-128 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |
| 34976861 | AGIA Tag System for Ultrastructural Protein Localization Analysis in Blood-StagePlasmodium falciparum. | Morita M, Kanoi BN, ..., Takashima E | 10.3389/fcimb.2021.777291 |
| 36403045 | Characterization of the primary antibody response to Plasmodium falciparumantigens in infants living in a malaria-endemic area | Tassi Yunga S, Siriwardhana C, ..., Taylor DW | 10.1186/s12936-022-04360-x |
| 37647112 | Timing of dense granule biogenesis in asexual malaria parasites | Vallintine T, van Ooij C | 10.1099/mic.0.001389 |
| 37961136 | Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats | Amen A, Yoo R, ..., Jore MM | 10.1101/2023.11.03.565335 |