PF3D7_0102700 (MaTrA)

Genome location: Pf3D7_01_v3:124,394..126,213(+)

Genome classification: Core

Function and Localization

Product Description: merozoite-associated tryptophan-rich antigen

SignalP Peptide: MIFHKCFKICSLSCTVLWVTA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.61	0.72
Trophozoite	expressed	0.12	0.94
Schizont	possibly expressed	0.12	0.93
Gametocyte	possibly expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0102700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.851 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0524300)

Relative Growth Rate: 0.57 ± 0.19
Confidence: 4.74

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2B3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145873

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	10	7	20
disruptive	8	33	14	65
missense	7	33	14	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	17	15	24
disruptive	14	64	32	75
missense	13	56	25	48

PlasmoDB Total SNPs: 101

Non-coding: 74 | Synonymous: 17 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 276 | Molecular Weight (kDa): 34.501

UniProt ID(s): Q6QUY6, Q8I2B3

PDB ID(s): None

Isoelectric Point: 6.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022089	Tryptophan/threonine-rich plasmodium antigen, C-terminal
PFam	PF12319	Tryptophan/threonine-rich plasmodium antigen, C-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
15383306	Characterisation of a tryptophan-rich Plasmodium falciparum antigen associatedwith merozoites.	Ntumngia FB, Bouyou-Akotet MK, ..., Kun JF	10.1016/j.molbiopara.2004.06.008