PF3D7_0102800

Genome location: Pf3D7_01_v3:125,835..128,373(-)

Genome classification: Core

Function and Localization

Product Description: seipin domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.37	0.77
Schizont	possibly expressed	0.08	0.94
Gametocyte	not expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0102800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.99 | MFS: -0.096 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0210300)

Modification: Disrupted | RMgm-4200

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2B2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532896

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	16	27
disruptive	24	93	52	103
missense	14	69	40	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	53	18	37
disruptive	58	211	84	173
missense	27	155	58	89

PlasmoDB Total SNPs: 112

Non-coding: 60 | Synonymous: 31 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 607 | Molecular Weight (kDa): 74.843

UniProt ID(s): Q8I2B2

PDB ID(s): None

Isoelectric Point: 8.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009617	Seipin family
PFam	PF06775	Seipin family
Superfamily	N/A	N/A