PF3D7_0103000

Genome location: Pf3D7_01_v3:131,609..134,133(-)

Genome classification: Core

Function and Localization

Product Description: vacuolar protein sorting-associated protein VTA1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005771	multivesicular body
Process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.08	0.95
Schizont	possibly expressed	0.10	0.93
Gametocyte	possibly expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0103000

Resistome Missense Mutations: L98F

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.123 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0210100)

Relative Growth Rate: 0.99 ± 0.11
Confidence: 5.80

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0210100)

Modification: Disrupted | RMgm-1710

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSH9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102826

Most Similar Human Ortholog: Q9NP79

TM-align score: 0.61 | RMSD: 3.17

Seq Identity: 0.19 | Length: 186 / 259

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000009844	vesicle trafficking 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	16	9	18
disruptive	4	26	15	34
missense	4	25	15	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	24	9	18
disruptive	6	61	29	70
missense	4	52	26	54

PlasmoDB Total SNPs: 115

Non-coding: 106 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 259 | Molecular Weight (kDa): 30.26

UniProt ID(s): B9ZSH9

PDB ID(s): None

Isoelectric Point: 4.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039431	Vta1/callose synthase, N-terminal
InterPro	IPR041212	Vta1, C-terminal
PFam	PF04652	Vta1/callose synthase, N-terminal
PFam	PF18097	Vta1, C-terminal
Superfamily	N/A	N/A