PF3D7_0103300

Genome location: Pf3D7_01_v3:143,389..146,959(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.44	0.78
Trophozoite	expressed	0.46	0.72
Schizont	expressed	0.24	0.85
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0103300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.961 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI0

"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.65) with 2QAF (Global RMSD=20.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532990

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	43	28	63
disruptive	49	161	71	169
missense	32	134	65	138

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	99	40	68
disruptive	91	324	137	301
missense	60	258	110	193

PlasmoDB Total SNPs: 126

Non-coding: 28 | Synonymous: 58 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 918 | Molecular Weight (kDa): 108.378

UniProt ID(s): B9ZSI0

PDB ID(s): None

Isoelectric Point: 7.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A