PF3D7_0103500

Genome location: Pf3D7_01_v3:153,669..160,630(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.41	0.76
Schizont	not expressed	0.16	0.90
Gametocyte	not expressed	0.60	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0103500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.989 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0209600)

Relative Growth Rate: 0.87 ± 0.37
Confidence: 3.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0209600)

Modification: Disrupted | RMgm-1707

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533411

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	92	62	104
disruptive	57	271	157	346
missense	40	238	143	299

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	173	68	115
disruptive	117	533	214	429
missense	82	448	181	329

PlasmoDB Total SNPs: 415

Non-coding: 196 | Synonymous: 114 | Nonsynonymous: 105 | Stop Codon: 0

Protein Information

Protein Length: 1823 | Molecular Weight (kDa): 219.415

UniProt ID(s): B9ZSI1

PDB ID(s): None

Isoelectric Point: 9.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A