Product Description: L-seryl-tRNA(Sec) kinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.1.164 (O-phosphoseryl-tRNA(Sec) kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0016301 | kinase activity |
| Function | GO:0000049 | tRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.94 |
| Trophozoite | expressed | 0.24 | 0.85 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.48 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0103700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.284 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2A3
"Best" AlphaFill ligand hit: HEX (hexane, Local RMSD=1.30) with 6JO0 (Global RMSD=21.55)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.1.164 | O-phosphoseryl-tRNASec kinase | tRNASec |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105960
Most Similar Human Ortholog: Q8IV42
TM-align score: 0.58 | RMSD: 4.14
Seq Identity: 0.20 | Length: 252 / 535
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000179988 | phosphoseryl-tRNA kinase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 26 | 15 | 36 |
| disruptive | 19 | 81 | 47 | 76 |
| missense | 19 | 78 | 42 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 52 | 35 | 39 |
| disruptive | 46 | 171 | 74 | 117 |
| missense | 36 | 138 | 61 | 74 |
PlasmoDB Total SNPs: 144
Non-coding: 102 | Synonymous: 20 | Nonsynonymous: 22 | Stop Codon: 0
Protein Length: 535 | Molecular Weight (kDa): 65.607
UniProt ID(s): Q8I2A3
PDB ID(s): None
Isoelectric Point: 10.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26586914 | Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase | Manhas R, Gowri VS, Madhubala R | 10.1074/jbc.M115.695007 |
| 32298370 | Proteomic analysis of infected primary human leucocytes revealed PSTK aspotential treatment-monitoring marker for active and latent tuberculosis | Kaewseekhao B, Roytrakul S, ..., Faksri K | 10.1371/journal.pone.0231834 |
| 35687481 | Phosphatidylserine and Phosphatidylethanolamine Asymmetry Have a Negligible Effect on the Global Structure, Dynamics, and Interactions of the KRAS Lipid Anchor | Araya MK, Gorfe AA | 10.1021/acs.jpcb.2c01253 |
| 32236652 | Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops | Krutyholowa R, Reinhardt-Tews A, ..., Glatt S | 10.1007/s00294-020-01070-2 |
| 28419530 | Differential expression profile analysis of PSTK-regulated mRNAs in podocytes | Zheng D, Zhao Y, ..., Xie K | 10.1002/jcb.26076 |
| 33417976 | Same but different - Molecular comparison of human KTI12 and PSTK | Smejda M, Kadziolka D, ..., Glatt S | 10.1016/j.bbamcr.2020.118945 |
| 30916349 | Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification byElongator | Krutyholowa R, Hammermeister A, ..., Glatt S | 10.1093/nar/gkz190 |
| 33017394 | Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase | da Silva MTA, Silva IRE, ..., Thiemann OH | 10.1371/journal.pntd.0008091 |
| 33224150 | Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia | Sherlock LG, Sjostrom K, ..., Wright CJ | 10.3389/fimmu.2020.595282 |