Product Description: actin-related protein ARP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0045177 | apical part of cell |
| Component | GO:0005869 | dynactin complex |
| Function | GO:0005200 | structural constituent of cytoskeleton |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.13 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0103800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.633 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2A2
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.16) with 2HMP (Global RMSD=2.23)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P60010 | Actin [R335K] | HOGENOM, OrthoDB | SCHEMBL1889389Latrunculin ASCHEMBL1889389Latrunculin A... |
Ortholog Group (OrthoMCL): OG6_103845
Most Similar Human Ortholog: P61163
TM-align score: 0.98 | RMSD: 0.86
Seq Identity: 0.60 | Length: 374 / 380
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115073 | actin related protein 1B |
| ENSG00000138107 | actin related protein 1A |
Protein Length: 380 | Molecular Weight (kDa): 42.698
UniProt ID(s): Q8I2A2
PDB ID(s): None
Isoelectric Point: 7.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004000 | Actin family |
| InterPro | IPR020902 | Actin/actin-like conserved site |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00022 | Actin family |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 29 | 18 | 29 |
| disruptive | 0 | 2 | 6 | 20 |
| missense | 0 | 2 | 6 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 63 | 18 | 23 |
| disruptive | 2 | 19 | 18 | 51 |
| missense | 0 | 15 | 17 | 32 |
PlasmoDB Total SNPs: 229
Non-coding: 208 | Synonymous: 18 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20580650 | Arp1, an actin-related protein, in Plasmodium berghei. | Siden-Kiamos I, Schuler H, Liakopoulos D, Louis C | 10.1016/j.molbiopara.2010.05.008 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 35337516 | Chemical structure and antioxidant activity of a neutral polysaccharide fromAsteris Radix et Rhizoma | Zhu Z, Song X, ..., Dai F | 10.1016/j.carbpol.2022.119309 |
| 33363697 | Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans | Yao S, Feng Y, ..., Feng J | 10.1016/j.csbj.2020.11.034 |