About Gene List

PF3D7_0104100

Genome location: Pf3D7_01_v3:177,187..181,825(+)

Genome classification: Core

Function and Localization

Product Description: protein E140, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0045178 basal part of cell
Component GO:0009986 cell surface
Component GO:0016020 membrane
Component GO:0020005 symbiont-containing vacuole membrane
Process GO:0052553 modulation by symbiont of host immune response

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite possibly expressed 0.09 0.94
Schizont possibly expressed 0.26 0.82
Gametocyte expressed 0.09 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0104100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.035 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0209000)

  • Relative Growth Rate: 0.48 ± 0.16
  • Confidence: 5.10

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0209000)

Modification: Disrupted | RMgm-1705

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I299

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532817

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 23 19 41
disruptive 86 57 43 91
missense 76 52 41 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 57 21 57
disruptive 103 114 78 138
missense 86 103 65 108

PlasmoDB Total SNPs: 346

Non-coding: 228 | Synonymous: 32 | Nonsynonymous: 86 | Stop Codon: 0

Protein Information

Protein Length: 791 | Molecular Weight (kDa): 92.736

UniProt ID(s): A0A650D649, A0A650D653, A0A650D672, A0A650D687, A0A650D690, A0A650D694, A0A650D6A3, A0A650D6B8, A0A650D6L3, A0A650D6L7, Q8I299

PDB ID(s): None

Isoelectric Point: 8.46

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606
32407410 Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterileprotection in mice against malaria challenge. Smith EC, Limbach KJ, ..., Aguiar JC 10.1371/journal.pone.0232234