Product Description: StAR-related lipid transfer protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0008525 | phosphatidylcholine transporter activity |
| Function | GO:0008526 | phosphatidylinositol transfer activity |
| Process | GO:2001139 | negative regulation of phospholipid transport |
| Process | GO:0015914 | phospholipid transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.56 | 0.78 |
| Trophozoite | expressed | 0.41 | 0.75 |
| Schizont | expressed | 0.80 | 0.60 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0104200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.28 | MFS: -3.379 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0208900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I298
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 25 | 12 | 22 |
| disruptive | 30 | 46 | 18 | 61 |
| missense | 21 | 33 | 13 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 50 | 7 | 25 |
| disruptive | 43 | 104 | 43 | 140 |
| missense | 28 | 67 | 27 | 84 |
PlasmoDB Total SNPs: 222
Non-coding: 172 | Synonymous: 25 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 466 | Molecular Weight (kDa): 53.626
UniProt ID(s): Q8I298
PDB ID(s): None
Isoelectric Point: 5.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF55961 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 18551176 | The malaria secretome: from algorithms to essential function in blood stageinfection. | van Ooij C, Tamez P, ..., Haldar K | https://pubmed.ncbi.nlm.nih.gov/18551176/ |
| 24043620 | Identification of a Plasmodium falciparum phospholipid transfer protein. | van Ooij C, Withers-Martinez C, ..., Blackman MJ | 10.1074/jbc.M113.474189 |
| 27694132 | Regulation and Essentiality of the StAR-related Lipid Transfer (START)Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites. | Hill RJ, Ringel A, ..., van Ooij C | 10.1074/jbc.M116.740506 |