PF3D7_0104500

Genome location: Pf3D7_01_v3:204,368..205,612(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MVSIFSLLTYIIYLYFSLKS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.55	0.75
Trophozoite	expressed	0.94	0.54
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.33	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0104500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -0.62 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I294

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110534

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	5	16
disruptive	2	10	10	23
missense	2	10	10	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	7	19
disruptive	2	25	18	35
missense	2	23	17	27

PlasmoDB Total SNPs: 34

Non-coding: 21 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 277 | Molecular Weight (kDa): 33.176

UniProt ID(s): Q8I294

PDB ID(s): None

Isoelectric Point: 8.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021610	Protein of unknown function DUF3228
PFam	PF11539	Protein of unknown function DUF3228
Superfamily	N/A	N/A