PF3D7_0104600

Genome location: Pf3D7_01_v3:205,812..210,273(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	possibly expressed	0.37	0.80
Schizont	possibly expressed	0.12	0.93
Gametocyte	not expressed	0.45	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0104600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.09 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533159

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	80	39	82
disruptive	55	233	129	255
missense	39	190	113	228

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	123	64	77
disruptive	116	438	157	300
missense	74	362	135	232

PlasmoDB Total SNPs: 245

Non-coding: 32 | Synonymous: 121 | Nonsynonymous: 92 | Stop Codon: 0

Protein Information

Protein Length: 1339 | Molecular Weight (kDa): 161.556

UniProt ID(s): B9ZSI2

PDB ID(s): None

Isoelectric Point: 9.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A