Product Description: major facilitator superfamily-related transporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005886 | plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.01 | 0.99 |
| Schizont | possibly expressed | 0.01 | 1.00 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0104700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.672 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0208400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0208400)
Modification: Disrupted | RMgm-1702
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I292
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 34 | 12 | 51 |
| disruptive | 51 | 93 | 53 | 106 |
| missense | 22 | 57 | 34 | 77 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 68 | 29 | 45 |
| disruptive | 81 | 179 | 80 | 173 |
| missense | 33 | 117 | 55 | 108 |
PlasmoDB Total SNPs: 72
Non-coding: 0 | Synonymous: 44 | Nonsynonymous: 28 | Stop Codon: 0
Protein Length: 711 | Molecular Weight (kDa): 83.692
UniProt ID(s): Q8I292
PDB ID(s): None
Isoelectric Point: 7.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34756057 | Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the MalariaParasite Plasmodium falciparum. | Wichers JS, van Gelder C, ..., Bachmann A | 10.1128/mSphere.00743-21 |