PF3D7_0105100

Genome location: Pf3D7_01_v3:220,727..221,928(+)

Genome classification: Core

Function and Localization

Product Description: conserved Apicomplexan protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	possibly expressed	0.04	0.97
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0105100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -3.051 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I290

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160718

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	4	13
disruptive	1	13	2	22
missense	1	13	2	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	12	12	16
disruptive	4	30	12	56
missense	2	27	11	35

PlasmoDB Total SNPs: 42

Non-coding: 31 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 143 | Molecular Weight (kDa): 17.066

UniProt ID(s): Q8I290

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A