Product Description: cyclase-associated protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030864 | cortical actin cytoskeleton |
| Function | GO:0003779 | actin binding |
| Function | GO:0003785 | actin monomer binding |
| Function | GO:0008179 | adenylate cyclase binding |
| Function | GO:0046983 | protein dimerization activity |
| Process | GO:0008154 | actin polymerization or depolymerization |
| Process | GO:0000902 | cell morphogenesis |
| Process | GO:0007163 | establishment or maintenance of cell polarity |
| Process | GO:0045761 | regulation of adenylate cyclase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.10 | 0.92 |
| Schizont | expressed | 0.75 | 0.59 |
| Gametocyte | possibly expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0105300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.141 | MFS: -3.448 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0208000)
Modification: Mutated | RMgm-386
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I288
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101374
Most Similar Human Ortholog: Q01518
TM-align score: 0.92 | RMSD: 1.44
Seq Identity: 0.36 | Length: 160 / 162
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112186 | cyclase associated actin cytoskeleton regulatory protein 2 |
| ENSG00000131236 | cyclase associated actin cytoskeleton regulatory protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 6 | 10 |
| disruptive | 2 | 8 | 7 | 26 |
| missense | 2 | 8 | 7 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 16 | 9 | 17 |
| disruptive | 2 | 31 | 12 | 51 |
| missense | 2 | 26 | 11 | 35 |
PlasmoDB Total SNPs: 62
Non-coding: 53 | Synonymous: 9 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 162 | Molecular Weight (kDa): 18.528
UniProt ID(s): Q8I288
PDB ID(s): None
Isoelectric Point: 4.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001837 | Adenylate cyclase-associated CAP |
| InterPro | IPR006599 | CARP motif |
| InterPro | IPR013912 | Adenylate cyclase-associated CAP, C-terminal |
| InterPro | IPR036223 | Adenylate cyclase-associated CAP, C-terminal superfamily |
| PFam | PF08603 | Adenylate cyclase-associated CAP, C-terminal |
| Superfamily | SSF69340 | Adenylate cyclase-associated CAP, C-terminal superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20083609 | Structure and function of a G-actin sequestering protein with a vital role inmalaria oocyst development inside the mosquito vector. | Hliscs M, Sattler JM, ..., Schuler H | 10.1074/jbc.M109.054916 |
| 38431113 | Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondiitachyzoites | Araujo-Silva CA, Vogerl K, ..., Vommaro RC | 10.1016/j.exppara.2024.108727 |