PF3D7_0105400

Genome location: Pf3D7_01_v3:226,036..227,419(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MRLWLIVCFLFLLSNNFIWA

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	possibly expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0105400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.929 | MFS: -2.495 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0207900)

Relative Growth Rate: 0.29 ± 0.16
Confidence: 5.02

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0207900)

Modification: Disrupted | RMgm-1699

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I287

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533750

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	9	6	3
disruptive	1	13	10	17
missense	1	13	7	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	6	4
disruptive	3	37	14	44
missense	2	30	14	26

PlasmoDB Total SNPs: 29

Non-coding: 20 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 140 | Molecular Weight (kDa): 16.856

UniProt ID(s): Q8I287

PDB ID(s): None

Isoelectric Point: 10.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A