About Gene List

PF3D7_0105500

Genome location: Pf3D7_01_v3:228,485..229,519(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.24 0.84
Schizont possibly expressed 0.03 0.98
Gametocyte not expressed 0.17 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0105500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.717 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0207800)

  • Relative Growth Rate: 0.07 ± 0.04
  • Confidence: 7.76

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0207800)

Modification: Other | RMgm-439

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I286

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139478

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 15 10 14
disruptive 2 11 25 49
missense 2 11 25 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 29 10 22
disruptive 4 54 32 77
missense 3 48 30 61

PlasmoDB Total SNPs: 9

Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 344 | Molecular Weight (kDa): 41.605

UniProt ID(s): Q8I286

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21
35984838 Mitochondrially targeted proximity biotinylation and proteomic analysis inPlasmodium falciparum. Lamb IM, Rios KT, ..., Vaidya AB 10.1371/journal.pone.0273357