About Gene List

PF3D7_0105700

Genome location: Pf3D7_01_v3:236,742..248,183(+)

Genome classification: Core

Function and Localization

Product Description: asparagine-rich antigen Pfa35-2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0048188 Set1C/COMPASS complex
Component GO:0005634 nucleus
Function GO:0003729 mRNA binding
Process GO:0051568 histone H3-K4 methylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.19 0.91
Trophozoite expressed 1.05 0.48
Schizont expressed 1.08 0.49
Gametocyte expressed 2.17 0.18

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0105700

Resistome Missense Mutations: K725Q, N2116K, N2211K

Resistome Compounds with Missense Mutations: BCH070, BI-2536, MMV019017

Resistome # Samples with Disruptive Mutations: 4 (3 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.851 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533614

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 38 150 74 157
disruptive 205 507 267 621
missense 117 375 223 507

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 60 257 126 206
disruptive 334 1029 446 870
missense 188 794 335 552

PlasmoDB Total SNPs: 551

Non-coding: 151 | Synonymous: 194 | Nonsynonymous: 206 | Stop Codon: 0

Protein Information

Protein Length: 3063 | Molecular Weight (kDa): 364.073

UniProt ID(s): Q03628, Q8I284

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0