About Gene List

PF3D7_0105800

Genome location: Pf3D7_01_v3:248,434..253,057(-)

Genome classification: Core

Function and Localization

Product Description: cyclin-dependent kinases regulatory subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite expressed 0.47 0.72
Schizont expressed 0.71 0.60
Gametocyte expressed 0.49 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0105800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.184 | MFS: -2.713 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0824400)

  • Relative Growth Rate: 0.96 ± 0.16
  • Confidence: 5.08

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I283

"Best" AlphaFill ligand hit: TQP (, Local RMSD=0.63) with 5U21 (Global RMSD=15.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100899

Most Similar Human Ortholog: P61024

TM-align score: 0.79 | RMSD: 1.86

Seq Identity: 0.25 | Length: 73 / 832

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000123975 CDC28 protein kinase regulatory subunit 2
ENSG00000173207 CDC28 protein kinase regulatory subunit 1B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 39 21 51
disruptive 19 52 39 122
missense 17 51 39 100

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 74 32 58
disruptive 29 152 97 181
missense 24 123 66 124

PlasmoDB Total SNPs: 309

Non-coding: 274 | Synonymous: 25 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 832 | Molecular Weight (kDa): 99.31

UniProt ID(s): Q8I283

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000789 Cyclin-dependent kinase, regulatory subunit
InterPro IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
PFam PF01111 Cyclin-dependent kinase, regulatory subunit
Superfamily SSF55637 Cyclin-dependent kinase, regulatory subunit superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108