PF3D7_0106000

Genome location: Pf3D7_01_v3:255,113..258,624(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.29	0.82
Schizont	expressed	0.79	0.58
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0106000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.188 | MFS: -2.706 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0207300)

Relative Growth Rate: 0.99 ± 0.15
Confidence: 5.13

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0207300)

Modification: Disrupted | RMgm-1695

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122704

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	47	18	40
disruptive	31	110	54	115
missense	20	76	34	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	84	43	53
disruptive	72	206	90	182
missense	45	128	60	113

PlasmoDB Total SNPs: 181

Non-coding: 9 | Synonymous: 107 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 922 | Molecular Weight (kDa): 109.28

UniProt ID(s): B9ZSI3

PDB ID(s): None

Isoelectric Point: 7.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A