Product Description: V-type proton ATPase subunit C, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain |
| Function | GO:0008553 | P-type proton-exporting transporter activity |
| Function | GO:0046961 | proton-transporting ATPase activity, rotational mechanism |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 0.65 | 0.63 |
| Schizont | expressed | 0.27 | 0.82 |
| Gametocyte | expressed | 0.53 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0106100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.999 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0207200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I280
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9U5N1 | V-type proton ATPase subunit C | OrthoDB | CHEMBL2203994 |
Ortholog Group (OrthoMCL): OG6_101992
Most Similar Human Ortholog: P21283
TM-align score: 0.79 | RMSD: 3.39
Seq Identity: 0.23 | Length: 351 / 383
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000155097 | ATPase H+ transporting V1 subunit C1 |
Protein Length: 383 | Molecular Weight (kDa): 45.26
UniProt ID(s): Q8I280
PDB ID(s): None
Isoelectric Point: 7.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004907 | ATPase, V1 complex, subunit C |
| InterPro | IPR036132 | Vacuolar ATP synthase subunit C superfamily |
| PFam | PF03223 | ATPase, V1 complex, subunit C |
| Superfamily | SSF118203 | Vacuolar ATP synthase subunit C superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 20 | 4 | 26 |
| disruptive | 2 | 6 | 5 | 18 |
| missense | 2 | 6 | 4 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 45 | 14 | 28 |
| disruptive | 6 | 30 | 23 | 79 |
| missense | 4 | 17 | 15 | 46 |
PlasmoDB Total SNPs: 133
Non-coding: 115 | Synonymous: 16 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |