PF3D7_0106200

Genome location: Pf3D7_01_v3:262,750..264,323(-)

Genome classification: Core

Function and Localization

Product Description: EF hand domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.17	0.90
Schizont	expressed	0.45	0.73
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0106200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.391 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0207100)

Relative Growth Rate: 0.47 ± 0.10
Confidence: 5.97

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0207100)

Modification: Disrupted | RMgm-1693

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533672

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	6	7	10
disruptive	6	22	17	35
missense	6	21	17	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	15	12	12
disruptive	12	62	27	76
missense	11	52	19	45

PlasmoDB Total SNPs: 70

Non-coding: 45 | Synonymous: 17 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 215 | Molecular Weight (kDa): 25.971

UniProt ID(s): B9ZSI4

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011992	EF-hand domain pair
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair