Product Description: calcium-transporting ATPase
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: 3.6.3.8 (Transferred entry: 7.2.2.10)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0005388 | P-type calcium transporter activity |
| Function | GO:0008553 | P-type proton-exporting transporter activity |
| Function | GO:0003723 | RNA binding |
| Process | GO:0070588 | calcium ion transmembrane transport |
| Process | GO:0006816 | calcium ion transport |
| Process | GO:0006874 | cellular calcium ion homeostasis |
| Process | GO:0042493 | response to drug |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.93 | 0.58 |
| Trophozoite | expressed | 1.16 | 0.43 |
| Schizont | expressed | 0.97 | 0.52 |
| Gametocyte | expressed | 0.72 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0106300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.131 | MFS: -2.942 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0610400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q76NN8
"Best" AlphaFill ligand hit: PCW ((z,z)-4-hydroxy-n,n,n-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium-4-oxide, Local RMSD=0.01) with 5XA8 (Global RMSD=7.43)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.8 | Ca2+-transporting ATPase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O14983 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Homo sapiens | HOGENOM, OrthoDB | CHEMBL191927CHEMBL362947CHEMBL191633CHEMBL365703... |
| Q93084 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | HOGENOM, OrthoDB | CAS# 88-58-4CHEBI:17734MLS000028812CHEMBL4534285... | |
| Q64518 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | HOGENOM, OrthoDB | 4-NONYLPHENOL | |
| O55143 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | HOGENOM, OMA, OrthoDB | 4-NONYLPHENOL | |
| P16615 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | OMA, OrthoDB | CHEBI:3962CHEMBL4534285CHEBI:17734CHEMBL4207081... | |
| P04191 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus | OrthoDB | hydroquinone derivative, 2bhydroquinone derivative, 2chydroquinone derivative, 3ahydroquinone derivative, 5a... |
| Q64541 | Sodium/potassium-transporting ATPase subunit alpha-4/beta-1 | OrthoDB | CHEMBL4095996CHEMBL4087192CHEMBL4072996CHEMBL4059538... | |
| P11507 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | OrthoDB | ABAMECTINBisphenol A (BPA) | |
| P05023 | Sodium/potassium-transporting ATPase subunit alpha-1 | OrthoDB | cid_439501DigoxigeninMLS000069819DOH (1)... | |
| P54707 | Potassium-transporting ATPase alpha chain 2 | Homo sapiens | OrthoDB | CHEMBL318786DigitoxigeninCHEMBL104027CHEMBL323301... |
| P50997 | Sodium/potassium-transporting ATPase subunit alpha-1 | Canis familiaris | OrthoDB | CHEMBL2068940MLS000069787DigitoxigeninMLS000069819... |
| P06685 | Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 | Rattus | OrthoDB | ABAMECTINcid_439501 |
| P19156 | Potassium-transporting ATPase alpha chain 1/subunit beta | OrthoDB | US9114126, MB7US10308605, Example 7US10308605, Example 11US10308605, Example 12... | |
| P20648 | Potassium-transporting ATPase alpha chain 1/subunit beta | Homo sapiens | OrthoDB | CHEMBL153567CHEMBL20364CHEMBL20372CHEMBL282218... |
| P05024 | Sodium/potassium-transporting ATPase subunit alpha-1 | Sus scrofa | OrthoDB | CHEMBL178993Uscharin derivativeUscharin derivativeCHEMBL175806 |
| P50993 | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 | OrthoDB | cid_439501DigoxigeninMLS000069819DOH (1)... |
Ortholog Group (OrthoMCL): OG6_100158
Most Similar Human Ortholog: P98194
TM-align score: 0.93 | RMSD: 2.14
Seq Identity: 0.34 | Length: 891 / 1228
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000017260 | ATPase secretory pathway Ca2+ transporting 1 |
| ENSG00000064270 | ATPase secretory pathway Ca2+ transporting 2 |
| ENSG00000074370 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
| ENSG00000174437 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
| ENSG00000196296 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 |
Protein Length: 1228 | Molecular Weight (kDa): 139.415
UniProt ID(s): E1CBY7, E1CC03, E1CC26, E1CC29, E1CC60, E1CCC2, E1CCC4, E5RU08, M9R131, Q5R2K6, Q76NN8
PDB ID(s): None
Isoelectric Point: 7.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001757 | P-type ATPase |
| InterPro | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| InterPro | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| InterPro | IPR008250 | P-type ATPase, A domain superfamily |
| InterPro | IPR018303 | P-type ATPase, phosphorylation site |
| InterPro | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| InterPro | IPR023299 | P-type ATPase, cytoplasmic domain N |
| InterPro | IPR036412 | HAD-like superfamily |
| PFam | PF00122 | Cation-transporting P-type ATPase, C-terminal |
| PFam | PF00689 | Cation-transporting P-type ATPase, N-terminal |
| PFam | PF00690 | |
| PFam | PF13246 | |
| Superfamily | SSF56784 | HAD-like superfamily |
| Superfamily | SSF81653 | P-type ATPase, A domain superfamily |
| Superfamily | SSF81660 | P-type ATPase, cytoplasmic domain N |
| Superfamily | SSF81665 | P-type ATPase, transmembrane domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 66 | 37 | 101 |
| disruptive | 24 | 76 | 55 | 236 |
| missense | 21 | 70 | 54 | 217 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 130 | 61 | 100 |
| disruptive | 35 | 193 | 122 | 282 |
| missense | 29 | 169 | 116 | 213 |
PlasmoDB Total SNPs: 291
Non-coding: 234 | Synonymous: 34 | Nonsynonymous: 23 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8314897 | Cloning of a Ca(2+)-ATPase gene of Plasmodium falciparum and comparison withvertebrate Ca(2+)-ATPases. | Kimura M, Yamaguchi Y, Takada S, Tanabe K | 10.1242/jcs.104.4.1129 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15937493 | A single amino acid residue can determine the sensitivity of SERCAs toartemisinins. | Uhlemann AC, Cameron A, ..., Krishna S | 10.1038/nsmb947 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |