About Gene List

PF3D7_0106600

Genome location: Pf3D7_01_v3:279,115..280,014(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKYILLFYTLVIFFYNTQY

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044538 host cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite possibly expressed 0.01 0.99
Schizont not expressed 0.10 0.94
Gametocyte not expressed 0.02 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0106600

Resistome Missense Mutations: N98K, L101Q, L117Q

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.964 | MFS: -2.138 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I276

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532741

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 16 13 17
disruptive 9 43 20 67
missense 7 37 14 47

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 37 14 22
disruptive 22 98 39 91
missense 13 73 29 50

PlasmoDB Total SNPs: 36

Non-coding: 0 | Synonymous: 23 | Nonsynonymous: 10 | Stop Codon: 3

Protein Information

Protein Length: 299 | Molecular Weight (kDa): 36.474

UniProt ID(s): Q8I276

PDB ID(s): None

Isoelectric Point: 10.71

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213