Product Description: small ribosomal subunit assembling AARP2 protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030686 | 90S preribosome |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0034511 | U3 snoRNA binding |
| Process | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.00 | 0.55 |
| Trophozoite | expressed | 0.96 | 0.51 |
| Schizont | expressed | 0.52 | 0.71 |
| Gametocyte | expressed | 0.74 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0106700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.771 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0206600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I275
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.32) with 2CXX (Global RMSD=7.05)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102112
Most Similar Human Ortholog: Q14692
TM-align score: 0.63 | RMSD: 5.79
Seq Identity: 0.29 | Length: 938 / 1434
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165733 | BMS1 ribosome biogenesis factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 73 | 31 | 90 |
| disruptive | 119 | 247 | 129 | 245 |
| missense | 45 | 137 | 90 | 161 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 38 | 136 | 54 | 82 |
| disruptive | 175 | 437 | 163 | 369 |
| missense | 68 | 267 | 117 | 215 |
PlasmoDB Total SNPs: 354
Non-coding: 91 | Synonymous: 120 | Nonsynonymous: 143 | Stop Codon: 0
Protein Length: 1434 | Molecular Weight (kDa): 166.89
PDB ID(s): None
Isoelectric Point: 4.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007034 | Ribosome biogenesis protein BMS1/TSR1, C-terminal |
| InterPro | IPR012948 | AARP2CN |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR039761 | Ribosome biogenesis protein Bms1/Tsr1 |
| PFam | PF04950 | Ribosome biogenesis protein BMS1/TSR1, C-terminal |
| PFam | PF08142 | AARP2CN |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9247928 | Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionaryconserved protein whose repeats identify a new family of parasite antigens. | Barale JC, Attal-Bonnefoy G, ..., Langsley G | 10.1016/s0166-6851(97)00065-0 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |