Product Description: centrin-1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005814 | centriole |
| Component | GO:0005813 | centrosome |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0007099 | centriole replication |
| Process | GO:0000278 | mitotic cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0107000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -2.849 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1310400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I272
"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.10) with 5I0I (Global RMSD=8.90)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101416
Most Similar Human Ortholog: Q12798
TM-align score: 0.48 | RMSD: 2.30
Seq Identity: 0.59 | Length: 91 / 168
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147400 | centrin 2 |
| ENSG00000177143 | centrin 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 7 | 14 |
| disruptive | 0 | 1 | 3 | 36 |
| missense | 0 | 1 | 3 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 21 | 5 | 10 |
| disruptive | 1 | 8 | 17 | 46 |
| missense | 0 | 5 | 15 | 38 |
PlasmoDB Total SNPs: 157
Non-coding: 153 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 168 | Molecular Weight (kDa): 19.599
UniProt ID(s): Q8I272
PDB ID(s): None
Isoelectric Point: 4.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27560164 | Novel Centromeric Loci of the Wine and Beer Yeast Dekkera bruxellensis CEN1 andCEN2 | Ishchuk OP, Vojvoda Zeljko T, ..., Piskur J | 10.1371/journal.pone.0161741 |
| 18640595 | Dissection of centromeric DNA from yeast Yarrowia lipolytica and identificationof protein-binding site required for plasmid transmission | Yamane T, Sakai H, ..., Matsuoka M | 10.1263/jbb.105.571 |
| 17971862 | An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1 | Scott KC, White CV, Willard HF | 10.1371/journal.pone.0001099 |
| 19117951 | Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatinassembly in fission yeast | Dubey RN, Nakwal N, ..., Singh J | 10.1074/jbc.M806461200 |