PF3D7_0107100

Genome location: Pf3D7_01_v3:295,177..296,959(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	expressed	0.35	0.79
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.34	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0107100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.199 | MFS: -3.365 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0206200)

Relative Growth Rate: 0.15 ± 0.06
Confidence: 7.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I271

"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.55) with 6A2O (Global RMSD=17.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532903

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	23	7	36
disruptive	8	51	20	53
missense	6	49	18	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	43	21	41
disruptive	24	91	45	122
missense	13	82	36	86

PlasmoDB Total SNPs: 79

Non-coding: 38 | Synonymous: 29 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 543 | Molecular Weight (kDa): 65.667

UniProt ID(s): Q8I271

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A