PF3D7_0107200 (CCR4-3)

Genome location: Pf3D7_01_v3:297,189..299,513(+)

Genome classification: Core

Function and Localization

Product Description: CCR4 domain-containing protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0107200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.564 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0206100)

• Relative Growth Rate: 0.92 ± 0.16
• Confidence: 5.00

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0207500)

Modification: Disrupted | RMgm-4586

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI5

"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=0.23) with 3NGQ (Global RMSD=6.22)

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_132868

No human ortholog(s)

Protein Information

Protein Length: 337 | Molecular Weight (kDa): 39.699

UniProt ID(s): B9ZSI5

PDB ID(s): None

Isoelectric Point: 7.91

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 201

Non-coding: 188 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0