PF3D7_0107300

Genome location: Pf3D7_01_v3:299,464..301,151(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MIQFIKCFLLFILLYSSDIIIS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	possibly expressed	0.02	0.98
Gametocyte	expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0107300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.108 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I269

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532768

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	22	12	30
disruptive	2	29	26	76
missense	2	28	26	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	38	22	34
disruptive	6	84	52	101
missense	6	79	50	84

PlasmoDB Total SNPs: 72

Non-coding: 52 | Synonymous: 14 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 399 | Molecular Weight (kDa): 47.616

UniProt ID(s): Q8I269

PDB ID(s): None

Isoelectric Point: 7.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A