About Gene List

PF3D7_0107400 (ATPk)

Genome location: Pf3D7_01_v3:302,509..304,236(+)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.12 0.94
Trophozoite expressed 0.72 0.60
Schizont possibly expressed 0.25 0.84
Gametocyte expressed 1.04 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0107400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -2.433 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I267

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139433

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 157

Non-coding: 153 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 153 | Molecular Weight (kDa): 18.763

UniProt ID(s): Q8I267

PDB ID(s): None

Isoelectric Point: 10

Protein Domain Annotations:

Source Family ID Description
InterPro IPR029071 Ubiquitin-like domain superfamily
PFam N/A N/A
Superfamily SSF54236 Ubiquitin-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27594426 A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. Sidik SM, Huet D, ..., Lourido S 10.1016/j.cell.2016.08.019
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21