Product Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST3/OST6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0009986 | cell surface |
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0033644 | host cell membrane |
| Component | GO:0008250 | oligosaccharyltransferase complex |
| Function | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| Process | GO:0018279 | protein N-linked glycosylation via asparagine |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | not expressed | 0.25 | 0.85 |
| Schizont | not expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.62 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0107700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.479 | MFS: -1.084 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: B9ZSI6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 10 | 27 |
| disruptive | 5 | 25 | 21 | 55 |
| missense | 5 | 24 | 19 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 32 | 18 | 33 |
| disruptive | 15 | 65 | 43 | 131 |
| missense | 12 | 49 | 38 | 81 |
PlasmoDB Total SNPs: 20
Non-coding: 0 | Synonymous: 14 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 446 | Molecular Weight (kDa): 54.497
UniProt ID(s): B9ZSI6
PDB ID(s): None
Isoelectric Point: 8.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021149 | Oligosaccharyl transferase complex, subunit OST3/OST6 |
| PFam | PF04756 | Oligosaccharyl transferase complex, subunit OST3/OST6 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29132428 | Characterization of Pb51 in Plasmodium berghei as a malaria vaccine candidatetargeting both asexual erythrocytic proliferation and transmission. | Wang J, Zheng W, ..., Cui L | 10.1186/s12936-017-2107-2 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |