About Gene List

PF3D7_0107900

Genome location: Pf3D7_01_v3:326,323..327,365(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MLFLFLLLLFFIIHLSYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite possibly expressed 0.40 0.75
Schizont not expressed 0.05 0.97
Gametocyte not expressed 0.50 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0107900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.186 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I262

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532383

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 11 11 13
disruptive 3 31 9 47
missense 3 25 8 39

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 28 16 12
disruptive 22 70 31 85
missense 13 48 24 57

PlasmoDB Total SNPs: 40

Non-coding: 26 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 275 | Molecular Weight (kDa): 33.186

UniProt ID(s): Q8I262

PDB ID(s): None

Isoelectric Point: 10.37

Protein Domain Annotations:

Source Family ID Description
InterPro IPR012340 Nucleic acid-binding, OB-fold
PFam N/A N/A
Superfamily SSF50249 Nucleic acid-binding, OB-fold

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895