Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: MLFLFLLLLFFIIHLSYS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.08 | 0.96 |
Trophozoite | possibly expressed | 0.40 | 0.75 |
Schizont | not expressed | 0.05 | 0.97 |
Gametocyte | not expressed | 0.50 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0107900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -3.186 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I262
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 1 | 11 | 11 | 13 |
disruptive | 3 | 31 | 9 | 47 |
missense | 3 | 25 | 8 | 39 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 28 | 16 | 12 |
disruptive | 22 | 70 | 31 | 85 |
missense | 13 | 48 | 24 | 57 |
PlasmoDB Total SNPs: 40
Non-coding: 26 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 275 | Molecular Weight (kDa): 33.186
UniProt ID(s): Q8I262
PDB ID(s): None
Isoelectric Point: 10.37
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
PFam | N/A | N/A |
Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |