About Gene List

PF3D7_0108100

Genome location: Pf3D7_01_v3:330,597..332,834(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite possibly expressed 0.39 0.76
Schizont possibly expressed 0.19 0.88
Gametocyte expressed 0.76 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.133 | MFS: -2.879 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0205300)

  • Relative Growth Rate: 0.05 ± 0.04
  • Confidence: 8.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I260

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139434

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 24 22 38
disruptive 7 41 23 97
missense 7 40 22 86

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 49 26 46
disruptive 19 111 70 167
missense 13 97 52 120

PlasmoDB Total SNPs: 74

Non-coding: 27 | Synonymous: 26 | Nonsynonymous: 20 | Stop Codon: 1

Protein Information

Protein Length: 656 | Molecular Weight (kDa): 78.67

UniProt ID(s): Q8I260

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21