About Gene List

PF3D7_0108300 (ARP)

Genome location: Pf3D7_01_v3:334,374..344,369(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm
Component GO:0044228 host cell surface
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 2.43 0.14
Trophozoite expressed 1.96 0.19
Schizont expressed 1.53 0.29
Gametocyte expressed 1.24 0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108300

Resistome Missense Mutations: S636N, S637N, G639D

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 8 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.611 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I259

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533181

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 66 127 68 148
disruptive 218 378 180 424
missense 74 214 118 301

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 89 256 90 143
disruptive 323 697 318 639
missense 122 413 232 396

PlasmoDB Total SNPs: 557

Non-coding: 222 | Synonymous: 188 | Nonsynonymous: 147 | Stop Codon: 0

Protein Information

Protein Length: 2221 | Molecular Weight (kDa): 254.993

UniProt ID(s): O96422, Q8I259

PDB ID(s): None

Isoelectric Point: 5.38

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF52047 N/A

Associated Publications

PMID Title Authors DOI/Link
10599917 Cloning and characterization of a new asparagine-rich protein in Plasmodiumfalciparum. Zhang K, Fujioka H, ..., Kumar N 10.1007/s004360050666
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0