PF3D7_0108400

Genome location: Pf3D7_01_v3:344,373..347,320(-)

Genome classification: Core

Function and Localization

Product Description: mitochondrial carrier protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.123 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0205100)

Relative Growth Rate: 0.99 ± 0.14
Confidence: 5.37

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0205100)

Modification: Disrupted | RMgm-1680

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107804

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	21	17	19
disruptive	6	14	8	38
missense	5	14	8	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	47	19	24
disruptive	10	42	35	90
missense	9	32	22	65

PlasmoDB Total SNPs: 157

Non-coding: 138 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 330 | Molecular Weight (kDa): 38.977

UniProt ID(s): B9ZSI7

PDB ID(s): None

Isoelectric Point: 9.68

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018108	Mitochondrial substrate/solute carrier
InterPro	IPR023395	Mitochondrial carrier domain superfamily
PFam	PF00153	Mitochondrial substrate/solute carrier
Superfamily	SSF103506	Mitochondrial carrier domain superfamily