PF3D7_0108500

Genome location: Pf3D7_01_v3:347,246..350,568(+)

Genome classification: Core

Function and Localization

Product Description: ELM2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	3.26	0.11
Trophozoite	expressed	1.14	0.48
Schizont	expressed	1.03	0.50
Gametocyte	expressed	0.78	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I257

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160333

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

PlasmoDB Total SNPs: 326

Non-coding: 310 | Synonymous: 2 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 179 | Molecular Weight (kDa): 19.734

UniProt ID(s): Q8I257

PDB ID(s): None

Isoelectric Point: 3.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000949	ELM2 domain
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
15477199	Myosin-like sequences in the malaria parasite Plasmodium falciparum bind humanerythrocyte membrane protein 4.1.	Lanzillotti R, Coetzer TL	https://pubmed.ncbi.nlm.nih.gov/15477199/
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g