About Gene List

PF3D7_0108600

Genome location: Pf3D7_01_v3:348,892..351,747(-)

Genome classification: Core

Function and Localization

Product Description: DnaJ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.09 0.95
Trophozoite expressed 0.36 0.78
Schizont expressed 0.09 0.94
Gametocyte expressed 0.49 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.19 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I256

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139454

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 22 13 22
disruptive 11 56 27 48
missense 9 54 24 40

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 38 20 21
disruptive 26 98 37 82
missense 19 89 32 60

PlasmoDB Total SNPs: 116

Non-coding: 98 | Synonymous: 8 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 306 | Molecular Weight (kDa): 37.638

UniProt ID(s): Q8I256

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036869 Chaperone J-domain superfamily
PFam N/A N/A
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21