About Gene List

PF3D7_0108700 (PSOP24)

Genome location: Pf3D7_01_v3:351,787..356,984(-)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MKFYSTFVICFIILKVCLS

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.64 0.71
Trophozoite expressed 1.14 0.43
Schizont expressed 0.62 0.65
Gametocyte expressed 0.91 0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.113 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I255

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_170441

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 50 35 63
disruptive 97 204 105 235
missense 52 143 75 178

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 118 37 59
disruptive 147 413 142 301
missense 73 296 110 204

PlasmoDB Total SNPs: 409

Non-coding: 169 | Synonymous: 130 | Nonsynonymous: 110 | Stop Codon: 0

Protein Information

Protein Length: 1152 | Molecular Weight (kDa): 135.625

UniProt ID(s): Q8I255

PDB ID(s): None

Isoelectric Point: 4.98

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF141571 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895