PF3D7_0108800

Genome location: Pf3D7_01_v3:357,279..360,804(+)

Genome classification: Core

Function and Localization

Product Description: mitochondrial carrier protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.11	0.94
Trophozoite	expressed	0.56	0.67
Schizont	expressed	0.29	0.81
Gametocyte	expressed	0.45	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0108800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.102 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I254

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	20	11	18
disruptive	3	17	10	17
missense	3	17	10	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	42	13	22
disruptive	5	40	22	82
missense	5	30	18	60

PlasmoDB Total SNPs: 308

Non-coding: 295 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 360 | Molecular Weight (kDa): 42.501

UniProt ID(s): Q8I254

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018108	Mitochondrial substrate/solute carrier
InterPro	IPR023395	Mitochondrial carrier domain superfamily
PFam	PF00153	Mitochondrial substrate/solute carrier
Superfamily	SSF103506	Mitochondrial carrier domain superfamily