Product Description: LCCL domain-containing protein
SignalP Peptide: MLKITCVGLFFYIIKS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044312 | crystalloid |
| Component | GO:0005788 | endoplasmic reticulum lumen |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.95 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.18 | 0.90 |
| Gametocyte | expressed | 0.64 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0109100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.243 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1315300)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0204500)
Modification: Tagged | RMgm-1473
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I252
"Best" AlphaFill ligand hit: INS (myo-inositol, Local RMSD=1.37) with 3EA2 (Global RMSD=18.34)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 30 | 68 |
| disruptive | 13 | 42 | 37 | 117 |
| missense | 10 | 42 | 35 | 103 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 81 | 41 | 69 |
| disruptive | 25 | 112 | 73 | 193 |
| missense | 16 | 102 | 62 | 147 |
PlasmoDB Total SNPs: 87
Non-coding: 41 | Synonymous: 34 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 1029 | Molecular Weight (kDa): 118.533
UniProt ID(s): Q8I252
PDB ID(s): None
Isoelectric Point: 6.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004043 | LCCL domain |
| InterPro | IPR008979 | Galactose-binding-like domain superfamily |
| InterPro | IPR011658 | PA14 domain |
| InterPro | IPR036609 | LCCL domain superfamily |
| PFam | PF03815 | LCCL domain |
| PFam | PF07691 | PA14 domain |
| Superfamily | SSF49785 | Galactose-binding-like domain superfamily |
| Superfamily | SSF56988 | LCCL domain superfamily |
| Superfamily | SSF69848 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19932717 | Plasmodium berghei crystalloids contain multiple LCCL proteins. | Saeed S, Carter V, Tremp AZ, Dessens JT | https://pubmed.ncbi.nlm.nih.gov/19932717/ |
| 25900212 | Biogenesis of the crystalloid organelle in Plasmodium involvesmicrotubule-dependent vesicle transport and assembly. | Saeed S, Tremp AZ, Dessens JT | 10.1016/j.ijpara.2015.03.002 |
| 35242841 | Identification of CCp5 and FNPA as Novel Non-canonical Members of the CCp ProteinFamily in Babesia bovis | Ozubek S, Alzan HF, ..., Suarez CE | 10.3389/fvets.2022.833183 |