Product Description: elongation of fatty acids protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: 2.3.1.199 (Very-long-chain 3-oxoacyl-CoA synthase);6.2.1.3 (Long-chain-fatty-acid--CoA ligase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0009922 | fatty acid elongase activity |
| Process | GO:0034625 | fatty acid elongation, monounsaturated fatty acid |
| Process | GO:0034626 | fatty acid elongation, polyunsaturated fatty acid |
| Process | GO:0019367 | fatty acid elongation, saturated fatty acid |
| Process | GO:0030148 | sphingolipid biosynthetic process |
| Process | GO:0042761 | very long-chain fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.15 | 0.91 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.55 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0109300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.168 | MFS: -2.779 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I251
"Best" AlphaFill ligand hit: 37X (octyl glucose neopentyl glycol, Local RMSD=0.02) with 6Y7F (Global RMSD=10.70)
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9H5J4 | Elongation of very long chain fatty acids protein 6 | Homo sapiens | OMA, OrthoDB | CHEMBL470730CHEMBL452144CHEMBL522448CHEMBL523485... |
| Q920L5 | Elongation of very long chain fatty acids protein 6 | Mus musculus | OMA, OrthoDB | CHEMBL449121CHEMBL578249CHEMBL572158CHEMBL571698... |
| Q9HB03 | Elongation of very long chain fatty acids protein 3 | Homo sapiens | OrthoDB | CHEMBL490750CHEMBL491944CHEMBL491949CHEMBL493642... |
| O35949 | Elongation of very long chain fatty acids protein 3 | Mus musculus | OrthoDB | CHEMBL449121CHEMBL578249CHEMBL570571 |
Ortholog Group (OrthoMCL): OG6_100813
Most Similar Human Ortholog: Q9H5J4
TM-align score: 0.93 | RMSD: 1.68
Seq Identity: 0.29 | Length: 261 / 322
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119915 | ELOVL fatty acid elongase 3 |
| ENSG00000170522 | ELOVL fatty acid elongase 6 |
Protein Length: 322 | Molecular Weight (kDa): 39.288
UniProt ID(s): Q8I251
PDB ID(s): None
Isoelectric Point: 9.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002076 | ELO family |
| InterPro | IPR030457 | ELO family, conserved site |
| PFam | PF01151 | ELO family |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 5 | 12 |
| disruptive | 1 | 11 | 15 | 26 |
| missense | 1 | 9 | 13 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 9 | 27 |
| disruptive | 8 | 46 | 31 | 71 |
| missense | 4 | 33 | 21 | 47 |
PlasmoDB Total SNPs: 86
Non-coding: 62 | Synonymous: 21 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22179608 | Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis inapicomplexan parasite Toxoplasma gondii. | Ramakrishnan S, Docampo MD, ..., Striepen B | 10.1074/jbc.M111.310144 |