Product Description: tubulin-specific chaperone a, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005829 | cytosol |
Component | GO:0015630 | microtubule cytoskeleton |
Function | GO:0015631 | tubulin binding |
Function | GO:0051082 | unfolded protein binding |
Process | GO:0006457 | protein folding |
Process | GO:0065003 | protein-containing complex assembly |
Process | GO:0007021 | tubulin complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | possibly expressed | 0.11 | 0.95 |
Trophozoite | expressed | 0.35 | 0.80 |
Schizont | expressed | 0.10 | 0.94 |
Gametocyte | expressed | 1.78 | 0.26 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0109400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.24 | MFS: -3.364 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0204200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0204200)
Modification: Disrupted | RMgm-1678
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I250
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=9.91) with 3PLA (Global RMSD=13.38)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102635
Most Similar Human Ortholog: O75347
TM-align score: 0.86 | RMSD: 1.97
Seq Identity: 0.25 | Length: 108 / 166
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000171530 | tubulin folding cofactor A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 127
Non-coding: 119 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 166 | Molecular Weight (kDa): 19.591
UniProt ID(s): Q8I250
PDB ID(s): None
Isoelectric Point: 5.23
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR004226 | Tubulin binding cofactor A |
InterPro | IPR036126 | Tubulin binding cofactor A superfamily |
PFam | PF02970 | Tubulin binding cofactor A |
Superfamily | SSF46988 | Tubulin binding cofactor A superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |