Product Description: cold-shock protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Function | GO:0003723 | RNA binding |
| Function | GO:0043014 | alpha-tubulin binding |
| Function | GO:0048487 | beta-tubulin binding |
| Function | GO:0003690 | double-stranded DNA binding |
| Function | GO:0003730 | mRNA 3'-UTR binding |
| Process | GO:0035556 | intracellular signal transduction |
| Process | GO:0043488 | regulation of mRNA stability |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.19 | 0.89 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0109600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.247 | MFS: -3.269 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I248
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 2 | 5 |
| disruptive | 3 | 22 | 8 | 24 |
| missense | 2 | 17 | 7 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 4 | 13 |
| disruptive | 11 | 45 | 25 | 46 |
| missense | 4 | 32 | 18 | 29 |
PlasmoDB Total SNPs: 46
Non-coding: 30 | Synonymous: 6 | Nonsynonymous: 9 | Stop Codon: 1
Protein Length: 150 | Molecular Weight (kDa): 17.99
UniProt ID(s): Q8I248
PDB ID(s): None
Isoelectric Point: 9.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002059 | Cold-shock protein, DNA-binding |
| InterPro | IPR011129 | Cold shock domain |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR019844 | Cold-shock (CSD) domain |
| PFam | PF00313 | Cold-shock protein, DNA-binding |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 33109193 | Pleiotropic roles of cold shock proteins with special emphasis on unexplored coldshock protein member of Plasmodium falciparum. | Behl A, Kumar V, Shevtsov M, Singh S | 10.1186/s12936-020-03448-6 |