About Gene List

PF3D7_0109700 (RRP36)

Genome location: Pf3D7_01_v3:378,653..380,086(-)

Genome classification: Core

Function and Localization

Product Description: rRNA biogenesis protein RRP36, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030686 90S preribosome
Component GO:0005730 nucleolus
Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 1.40 0.44
Trophozoite possibly expressed 0.78 0.60
Schizont not expressed 0.21 0.88
Gametocyte not expressed 0.88 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0109700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -2.586 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0203900)

  • Relative Growth Rate: 0.28 ± 0.11
  • Confidence: 5.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0203900)

Modification: Disrupted | RMgm-1677

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I247

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103080

Most Similar Human Ortholog: U3KPZ9

TM-align score: 0.86 | RMSD: 1.21

Seq Identity: 0.07 | Length: 29 / 183

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000124541 ribosomal RNA processing 36

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 5 11
disruptive 3 7 8 22
missense 3 5 7 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 16 12 10
disruptive 12 40 33 34
missense 5 22 27 18

PlasmoDB Total SNPs: 70

Non-coding: 57 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 2

Protein Information

Protein Length: 183 | Molecular Weight (kDa): 22.105

UniProt ID(s): Q8I247

PDB ID(s): None

Isoelectric Point: 10.88

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009292 rRNA biogenesis protein RRP36
PFam PF06102 rRNA biogenesis protein RRP36
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
20038530 Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA andproduction of the 40S ribosomal subunit Gerus M, Bonnart C, ..., Henras AK 10.1128/MCB.00999-09