Product Description: phosphatidate cytidylyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 14
EC Numbers: 2.7.1.108 (Dolichol kinase);2.7.7.41 (Phosphatidate cytidylyltransferase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020011 | apicoplast |
Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
Function | GO:0004168 | dolichol kinase activity |
Process | GO:0043048 | dolichyl monophosphate biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.05 | 0.97 |
Trophozoite | expressed | 0.46 | 0.75 |
Schizont | expressed | 0.50 | 0.72 |
Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0109900.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0203750)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: B9ZSI8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103187
Most Similar Human Ortholog: Q9UPQ8
TM-align score: 0.76 | RMSD: 4.17
Seq Identity: 0.16 | Length: 482 / 596
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000175283 | dolichol kinase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 26 | 11 | 51 |
disruptive | 10 | 62 | 48 | 82 |
missense | 8 | 56 | 46 | 71 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 56 | 32 | 55 |
disruptive | 29 | 178 | 62 | 135 |
missense | 16 | 136 | 57 | 97 |
PlasmoDB Total SNPs: 230
Non-coding: 178 | Synonymous: 42 | Nonsynonymous: 9 | Stop Codon: 1
Protein Length: 596 | Molecular Weight (kDa): 70.934
UniProt ID(s): B9ZSI8
PDB ID(s): None
Isoelectric Point: 9.64
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR026566 | Dolichol kinase |
InterPro | IPR032974 | Polyprenol kinase family |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |