About Gene List

PF3D7_0109850

Genome location: Pf3D7_01_v3:383,092..386,632(+)

Genome classification: Core

Function and Localization

Product Description: phosphatidate cytidylyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 14

EC Numbers: 2.7.1.108 (Dolichol kinase);2.7.7.41 (Phosphatidate cytidylyltransferase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0030176 integral component of endoplasmic reticulum membrane
Function GO:0004168 dolichol kinase activity
Process GO:0043048 dolichyl monophosphate biosynthetic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.05 0.97
Trophozoite expressed 0.46 0.75
Schizont expressed 0.50 0.72
Gametocyte expressed 0.25 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0109900.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0203750)

  • Relative Growth Rate: 0.01 ± 0.20
  • Confidence: 4.63

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI8

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.1.108 dolichol kinase ATPGTPCTPCDPEDTAdCDPTriton X-100chlorpromazineTrifluoperazine
2.7.7.41 phosphatidate cytidylyltransferase ATPCTPNEMCMPSDSCDPEDTAPCMBdCTPFeSO4CHAPSZWT-12...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103187

Most Similar Human Ortholog: Q9UPQ8

TM-align score: 0.76 | RMSD: 4.17

Seq Identity: 0.16 | Length: 482 / 596

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000175283 dolichol kinase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 26 11 51
disruptive 10 62 48 82
missense 8 56 46 71

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 56 32 55
disruptive 29 178 62 135
missense 16 136 57 97

PlasmoDB Total SNPs: 230

Non-coding: 178 | Synonymous: 42 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 596 | Molecular Weight (kDa): 70.934

UniProt ID(s): B9ZSI8

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source Family ID Description
InterPro IPR026566 Dolichol kinase
InterPro IPR032974 Polyprenol kinase family
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895