Product Description: respiratory chain complex 2 associated protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0045273 | respiratory chain complex II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.13 | 0.92 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.23 | 0.86 |
More info:
No corresponding Pf3D7v3 gene ID in resistome database
Zhang Phenotype: N/A
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0203650)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXB9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 9 | 11 | 13 |
| disruptive | 3 | 13 | 6 | 22 |
| missense | 3 | 13 | 6 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 20 | 8 | 6 |
| disruptive | 6 | 30 | 14 | 38 |
| missense | 5 | 25 | 12 | 30 |
PlasmoDB Total SNPs: 145
Non-coding: 126 | Synonymous: 14 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 167 | Molecular Weight (kDa): 19.545
UniProt ID(s): A0A143ZXB9
PDB ID(s): None
Isoelectric Point: 9.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |