PF3D7_0110000

Genome location: Pf3D7_01_v3:388,192..389,559(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.03	0.99
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.04	0.97
Gametocyte	expressed	1.82	0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0110000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.016 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I244

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532923

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	8	5	17
disruptive	4	23	15	31
missense	4	23	15	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	19	12	16
disruptive	8	53	37	63
missense	7	46	28	42

PlasmoDB Total SNPs: 47

Non-coding: 33 | Synonymous: 5 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 27.847

UniProt ID(s): Q8I244

PDB ID(s): None

Isoelectric Point: 6.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A