Product Description: FAD-linked sulfhydryl oxidase ERV1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.8.3.2 (Thiol oxidase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0050660 | flavin adenine dinucleotide binding |
| Function | GO:0016971 | flavin-linked sulfhydryl oxidase activity |
| Function | GO:0015035 | protein-disulfide reductase activity |
| Process | GO:0008283 | cell population proliferation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.22 | 0.86 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0110200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.208 | MFS: -2.71 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0203400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I242
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.02) with 3MBG (Global RMSD=1.13)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.8.3.2 | thiol oxidase | KINEMKCNDTTEDTAGSSGRNAiazideZnSO4MgSO4Na2SO4guanine... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101299
Most Similar Human Ortholog: H3BQQ4
TM-align score: 0.76 | RMSD: 1.90
Seq Identity: 0.35 | Length: 108 / 143
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000127554 | growth factor, augmenter of liver regeneration |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 138
Non-coding: 126 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 143 | Molecular Weight (kDa): 17.161
UniProt ID(s): Q8I242
PDB ID(s): None
Isoelectric Point: 8.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR017905 | ERV/ALR sulfhydryl oxidase domain |
| InterPro | IPR036774 | ERV/ALR sulfhydryl oxidase domain superfamily |
| InterPro | IPR039799 | Sulfhydryl oxidase ALR/ERV |
| PFam | PF04777 | ERV/ALR sulfhydryl oxidase domain |
| Superfamily | SSF69000 | ERV/ALR sulfhydryl oxidase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |