About Gene List

PF3D7_0110500 (BDP3)

Genome location: Pf3D7_01_v3:396,580..403,838(+)

Genome classification: Core

Function and Localization

Product Description: bromodomain protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0035267 NuA4 histone acetyltransferase complex
Component GO:0005634 nucleus
Process GO:0016573 histone acetylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.42 0.80
Trophozoite expressed 1.10 0.46
Schizont expressed 0.32 0.81
Gametocyte expressed 1.19 0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0110500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.257 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I240

"Best" AlphaFill ligand hit: BMF (bromosporine, Local RMSD=0.19) with 5U9N (Global RMSD=2.34)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532831

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 99 52 111
disruptive 163 333 188 380
missense 79 228 143 287

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 43 188 71 107
disruptive 239 671 305 536
missense 114 471 231 296

PlasmoDB Total SNPs: 447

Non-coding: 80 | Synonymous: 219 | Nonsynonymous: 148 | Stop Codon: 0

Protein Information

Protein Length: 2285 | Molecular Weight (kDa): 268.207

UniProt ID(s): Q8I240

PDB ID(s): 4PY6

Isoelectric Point: 6.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001487 Bromodomain
InterPro IPR036427 Bromodomain-like superfamily
PFam N/A N/A
Superfamily SSF47370 Bromodomain-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108